产品名称

Mexiletine HCl(盐酸美西律)

一般描述

Mexiletine HCl belongs to Class IB anti-arrhythmic group of medicines, inhibits sodium channels to reduce the inward sodium current.

别 称

KO1173; 1-(2,6-dimethylphenoxy)propan-2-amine; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

5370-01-4

分子式

C¹¹H¹⁸ClNO

分子量

215.721

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥35mg/ml

水

≥35mg/ml

l  生物学信息

生物活性/药理作用

Mexiletine Hydrochloride is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system.

应 用

1.Anti-Arrhythmia Agents

2.Voltage-Gated Sodium Channel Blockers

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov