产品名称

Bromfenac Sodium(溴芬酸钠)

一般描述

Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

别 称

AHR 10282R; sodium; 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate

纯 度

≥98.0%(HPLC)

CAS NO.

91714-93-1

分子式

C¹⁵H¹¹BrNNaO³

分子量

356.151

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色至深黄色固体

溶解性(25°C)

DMSO

≥25mg/ml

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov