Mechlorethamine HCl
商品编号：
TS1858
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详细介绍
l 基本信息 |
产品名称 | Mechlorethamine HCl(氮芥盐酸盐) |
一般描述 | Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crossing two strands and preventing cell duplication. |
别 称 | 2-chloro-N-(2-chloroethyl)-N-methylethanamine; hydrochloride |
纯 度 | ≥98.0%(T) | CAS NO. | 55-86-7 |
分子式 | C5H12Cl3N | 分子量 | 192.508 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至类白色固体 |
溶解性(25°C) | DMSO | ≥25mg/ml |
水 | ≥25mg/ml |
l 生物学信息 |
生物活性/药理作用 | Mechlorethamine Hydrochloride is the hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crossing, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis.This agent also exhibits lympholytic properties. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
