产品名称

Epinastine HCl(依匹斯汀盐酸盐)

一般描述

Epinastine is an antihistamine and mast cell stabilizer that is used in eye drops to  treat allergic conjunctivitis.

别 称

WAL-801CL HCl; 2,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

108929-04-0

分子式

C¹⁶H¹⁶ClN³

分子量

285.775

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥45mg/ml

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Epinastine Hydrochloride is an histamine H1 receptor antagonist without sedative activity. Epinastine hydrochloride blocks the histamine H1 receptor and inhibits the release of histamine from mast cells. This prevents the typical allergic symptoms that are caused by histamine  activity on capillaries, skin, mucous membranes, and on gastrointestinal and bronchial smooth muscles. Typical histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Epinastine also has affinity for the histamine  H2, 5-HT2, and the alpha-1, alpha-2 adrenergic receptors.

应 用

Histamine H1 Antagonists

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov