产品名称

Quinacrine 2HCl(喹吖因二盐酸)

一般描述

Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.

别 称

4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine; dihydrochloride

纯 度

≥90.0%(HPLC)

CAS NO.

69-05-6

分子式

C²³H³²Cl³N³O

分子量

472.879

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥5mg/ml

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the tranion and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 tranion, the restoration of p53-dependent apoptotic  pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present  in many tumors and in chronic inflammatory processes, promotes the of antiapoptotic proteins and cytokines while downregulating the of proapoptotic proteins, such as p53.

应 用

1.Antimalarials

2.Antineoplastic Agents

3.Enzyme Inhibitors

4.Anticestodal Agents

5.Antinematodal Agents

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov