产品名称

Demeclocycline HCl(盐酸地美环素)

一般描述

Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by   bacteria, used for the treatment of bacterial infections. 

别 称

(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide; hydrochloride

纯 度

≥90.0%(HPLC)

CAS NO.

64-73-3

分子式

C²¹H²²Cl²N²O⁸

分子量

501.313

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色固体

溶解性(25°C)

DMSO

≥50mg/ml

水

≥15mg/ml

l  生物学信息

生物活性/药理作用

Demeclocycline Hydrochloride is the hydrochloride salt of demeclocycline, a broad-spectrum, tetracycline derivative exhibiting antimicrobial, aquaretic and chelating activities. In bacteria, demeclocycline binds reversibly to the 30S ribosomal subunit and blocks the binding of aminoacyl-tRNA to the A-site of the mRNA-ribosome complex, resulting in the   inhibition of protein synthesis and bacterial cell death. In mammals, this agent interferes with the action of antidiuretic hormone (ADH) at the level of the renal collecting tubule, resulting in aquaresis. In addition, demeclocycline, which like other tetracyclines chelates calcium in bone and exhibits a yellow fluorescence under ultraviolet (UV) light, may be used as a fluorescent bone-labeling agent in bone histomorphometry.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov