产品名称

Metoclopramide HCl(盐酸甲氧氯普)

一般描述

Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. 

别 称

4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

7232-21-5

分子式

C¹⁴H²³Cl²N³O²

分子量

336.257

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥50mg/ml

水

≥50mg/ml

l  生物学信息

生物活性/药理作用

Metoclopramide Hydrochloride is the hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic  acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2(D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.

应 用

1.Dopamine D2 Receptor Antagonists

2.Antiemetics

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov