产品名称

Labetalol HCl

一般描述

Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nive beta-adrenergic receptors, used in the treatment of high blood pressure.

别 称

2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide; hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

32780-64-6

分子式

C¹⁹H²⁵ClN²O³

分子量

364.87

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥50mg/ml

水

~5mg/ml

l  生物学信息

生物活性/药理作用

Labetalol Hydrochloride is the hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell  function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative  chronotropic and inotropic cardiac effects.

应 用

1.Antihypertensive Agents

2.Adrenergic alpha-1 Receptor Antagonists

3.Adrenergic beta-Antagonists

4.Sympathomimetics

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov