产品名称

Amifostine(氨磷汀)

一般描述

Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. 

别 称

2-(3-aminopropylamino)ethylsulfanylphosphonic acid; trihydrate

纯 度

≥97.0%(T)

CAS NO.

112901-68-5

分子式

C⁵H²¹N²O⁶PS

分子量

268.265

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

Very slightly soluble

水

≥35mg/ml

l  生物学信息

生物活性/药理作用

Amifostine  is the trihydrate form of a phosphorylated aminosulfhydryl compound. After   dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing   metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.

应 用

Radiation-Protective Agents

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov