产品名称

6-Mercaptopurine (6-MP) Monohydrate(6-巯基嘌呤一水合物)

一般描述

6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. 

别 称

3,7-dihydropurine-6-thione; hydrate

纯 度

≥99.0%(HPLC)

CAS NO.

6112-76-1

分子式

C⁵H⁶N⁴OS

分子量

170.19

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色固体

溶解性(25°C)

DMSO

≥25mg/ml

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Mercaptopurine is a thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurinemetabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine  methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis.

应 用

1.Antimetabolites

2.Antimetabolites, Antineoplastic

3.Immunosuppressive Agents

4.Nucleic Acid Synthesis Inhibitors

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov