产品名称

Azelaic acid(壬二酸)

一般描述

Azelaic acid is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

别 称

Nonanedioic acid, Finacea, Azelex, Anchoic acid; nonanedioic acid

纯 度

≥98.0%(GC)

CAS NO.

123-99-9

分子式

C⁹H¹⁶O⁴

分子量

188.223

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至黄色固体

溶解性(25°C)

DMSO

≥25mg/ml

水

≥25mg/ml

l  生物学信息

生物活性/药理作用

Azelaic Acid is a naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic  acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen  radical. This drug is used topically to reduce inflammation associated with acne and rosacea.

应 用

1.Antineoplastic Agents

2.Dermatologic Agents

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov