产品名称

Cyproheptadine hydrochloride sesquihydrate(盐酸赛庚啶)

一般描述

Cyproheptadine hydrochloride is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.

别 称

Periactin hydrochloride, Peritol; 4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine; trihydrate; dihydrochloride

纯 度

≥99.0%(HPLC)

CAS NO.

41354-29-4

分子式

C²¹H²²ClNR

分子量

350.88

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至浅黄色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

~5mg/ml

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Cyproheptadine Hydrochloride is the hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov