产品名称

Glycopyrrolate(格隆溴铵)

一般描述

Glycopyrrolate is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.

别 称

Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Gastrodyn

纯 度

≥98.0%(HPLC)

CAS NO.

596-51-0

分子式

C¹⁹H²⁸BrNO³

分子量

398.33

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至棕褐色固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

≥35mg/ml

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Glycopyrrolate is a synthetic quaternary ammonium that is an anticholinergic agent with antispasmodic activity. Glycopyrrolate competitively binds to peripheral muscarinic receptors in the autonomic effector cells of, and inhibits cholinergic transmission in smooth muscle, cardiac muscle, the sinoatrial (SA) node, the atrioventricular (AV) node, exocrine glands and in the autonomic ganglia. Blockage of cholinergic transmission, in smooth muscle cells located in the gastrointestinal tract and the bladder, causes smooth muscle relaxation and prevents the occurrence of painful spasms. In addition, glycopyrrolate inhibits the release of gastric, pharyngeal, tracheal, and bronchial secretions.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov