产品名称

Psoralen(补骨脂素)

一般描述

Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.

别 称

psoralene, Ficusin, Furocoumarin, furo[3,2-g]chromen-7-one

纯 度

≥99.0%(HPLC)

CAS NO.

66-97-7

分子式

C¹¹H⁶O³

分子量

186.16

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至白色带黄色的固体

溶解性(25°C)

DMSO

≥15mg/ml

乙醇

Insoluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Psoralen is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crossing double-stranded nucleic acids.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov