产品名称

Tolmetin(托麦汀)

一般描述

Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.

别 称

Tolectin; 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid

纯 度

≥95.0%(HPLC)

CAS NO.

26171-23-3

分子式

C¹⁵H¹⁵NO³

分子量

257.28

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥45mg/ml

l  生物学信息

生物活性/药理作用

Tolmetin is an arylalkanoic acid and non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic activities. Although the exact mechanism through which tolmetin exerts its effects has yet to be fully elucidated, this agent appears to inhibit the enzyme prostaglandin synthase. This prevents the formation of prostaglandins from prostaglandin precursors, including the synthesis of the inflammatory prostaglandin E2 (PGE2) from the precursor prostaglandin H2  (PGH2). This prevents prostaglandin-mediated effects, including pain, inflammation and fever.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov