产品名称

Levocetirizine Dihydrochloride(盐酸左旋西替利嗪)

一般描述

Levocetirizine Dihydrochloride is the active R-enantiomer of cetirizine and represents a new second-generation histamine H1 antagonist.

别 称

(-)-Cetirizine Dihydrochloride

纯 度

≥99.0%(HPLC)

CAS NO.

130018-87-0

分子式

C²¹H²⁷Cl³N²O³

分子量

461.81

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥45mg/ml

乙醇

Slightly soluble

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Levocetirizine Dihydrochloride is the dihydrochloride salt form of the active levorotatory enantiomer of cetirizine, levocetirizine; a third generation, non-sedating, selective histamine H1 receptor antagonist, with antihistamine, anti-inflammatory and potential anti-angiogenic activities. Levocetirizine competes with endogenous histamine for binding at peripheral H1-receptor sites on the effector cell surface. This prevents the negative symptoms associated with histamine release and an allergic reaction. In addition, as histamine plays an important role in angiogenesis during an allergic inflammatory reaction, blocking the action of histamine may modulate the  of proangiogenic factors and thus may prevent angiogenesis. As a third-generation histamine H1 receptor antagonist, levocetirizine has fewer side effects than most second-generation antihistamines.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov