产品名称

Crisaborole (AN2728)(克瑞沙硼)

一般描述

Crisaborole is a small-molecule, boron-based, selective PDE4 inhibitor and has broad-spectrum anti-inflammatory activity.

别 称

4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile

纯 度

≥98.0%(HPLC)

CAS NO.

906673-24-3

分子式

C¹⁴H¹⁰BNO³

分子量

251.05

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至米色固体

溶解性(25°C)

DMSO

≥35mg/ml

l  生物学信息

生物活性/药理作用

Crisaborole is a member of the class of benzoxaboroles that is 5-hydroxy-1,3-dihydro-2,1-benzoxaborole in which the phenolic hydrogen has been replaced by a 4-cyanophenyl group. A phosphodiesterase 4 inhibitor that is used for treatment of mild to moderate atopic dermatitis in children and adults. It has a role as a phosphodiesterase IV inhibitor, an antipsoriatic and a non-steroidal anti-inflammatory drug. It is a benzoxaborole, an aromatic ether and a nitrile.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov