产品名称

Revaprazan Hydrochloride(盐酸瑞伐拉赞)

一般描述

Revaprazan Hydrochloride is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects.

别 称

YH1885; N-(4-fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)pyrimidin-2-amine; hydrochloride 

纯 度

≥99.0%(HPLC)

CAS NO.

178307-42-1

分子式

C²²H²⁴ClFN⁴

分子量

398.9

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥5mg/ml

l  生物学信息

生物活性/药理作用

Revaprazan Hydrochloride is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity. Revaprazan concentrates highly in the gastric parietal cell canaliculus and on entering this acidic environment is instantly protonated and binds competitively and reversibly to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H₊/K₊ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H₊ ions into the gastric lumen, the final step in gastric acid production.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov