产品名称

Ganciclovir sodium(更昔洛韦钠)

一般描述

Ganciclovir sodium is an antiviral medication used to treat cytomegalovirus (CMV) infections

别 称

Natclovir; Cytovene IV; Ganciclovir Sodium Salt; sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate

纯 度

≥99.0%(HPLC)

CAS NO.

107910-75-8

分子式

C⁹H¹²N⁵NaO⁴

分子量

277.21

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

Insoluble

乙醇

Insoluble

水

≥45mg/ml

l  生物学信息

生物活性/药理作用

Ganciclovir Sodium is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV). Ganciclovir sodium is a prodrug that is phosphorylated and subsequently converted into its triphosphate form, the active metabolite ganciclovir-5-triphosphate (ganciclovir-TP), in the infected cells by cellular kinases. Ganciclovir-TP competes as a substrate with nucleotide triphosphates for viral DNA  polymerase. Once it gets incorporated into DNA strand, it prevents further polymerization of DNA, thereby interfering with viral DNA replication.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov