产品名称

Argatroban Monohydrate(阿加曲班一水合物)

一般描述

Argatroban is a direct, selective thrombin inhibitor with anticoagulant effects.

别 称

Argatroban hydrate, Argipidine

纯 度

≥99.0%(HPLC)

CAS NO.

141396-28-3

分子式

C²³H³⁸N⁶O⁶S

分子量

526.65

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥50mg/ml

乙醇

≥35mg/ml

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Argatroban is a synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site thereby preventing the thrombin-dependent reactions, which include conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban is highly selective for thrombin and is able to inhibit the action of both free and clot-associated thrombin. As a result, stabilization of blood clots and coagulation is inhibited.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov