产品名称

Calcium folinate(亚叶酸钙)

一般描述

Calcium folinate is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.

别 称

Leucovorin calcium, Folinic acid calcium salt

纯 度

≥99.0%(HPLC)

CAS NO.

1492-18-8

分子式

C²⁰H²¹CaN⁷O⁷

分子量

511.5

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色至橙色固体

溶解性(25°C)

DMSO

Very slightly soluble

水

≥50mg/ml

l  生物学信息

生物活性/药理作用

Leucovorin Calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov