产品名称

Nintedanib Ethanesulfonate Salt(尼达尼布乙磺酸盐)

一般描述

Nintedanib Ethanesulfonate Salt is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.

别 称

BIBF 1120 Ethanesulfonate Salt

纯 度

≥99.0%(HPLC)

CAS NO.

656247-18-6

分子式

C³³H³⁹N⁵O⁷S

分子量

649.76

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥50mg/ml

乙醇

Slightly soluble

水

≥50mg/ml

l  生物学信息

生物活性/药理作用

Nintedanib Esylate is a 28-mer RNA aptamer covalently ed to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity. Pegaptanib binds and blocks the activity of the extracellular vascular endothelial growth factor, specifically the 165-amino acid isoform (VEGF165). This prevents VEGF165 from binding to VEGF receptors, thereby blocking angiogenesis as well as preventing VEGF165-induced increases in vessel permeability. VEGF165 is preferentially involved in pathological ocular neovascularisation.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov