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详细介绍
l 基本信息 |
产品名称 | Entecavir(恩替卡韦) |
一般描述 | Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
别 称 | Entecavirum; Entecavir Anhydrous |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 142217-69-4 |
分子式 | C12H15N5O3 | 分子量 | 277.28 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至米色固体 |
溶解性(25°C) | DMSO | ≥45mg/ml |
乙醇 | Insoluble |
水 | Very slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Entecavir Anhydrous is an anhydrous formulation of entecavir, a synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse tranase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and tranion. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
