产品名称

Canrenone(坎利酮)

一般描述

Canrenone, a cardiovascular drug, a sort of steroid, is spironolactone's major metabolite and has been widely used as a nive aldosterone receptor antagonist clinically to treat heart failure, high blood pressure, edema, liver ascites, and other cardiovascular diseases.

别 称

Aldadiene, SC-9376, RP-11614

纯 度

≥98.0%(HPLC)

CAS NO.

976-71-6

分子式

C²²H²⁸O³

分子量

340.46

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥50mg/ml

l  生物学信息

生物活性/药理作用

Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. Canrenone is the primary active metabolite of both spironolactone and canreonate potassium.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov