产品名称

Rimantadine Hydrochloride(1-(1-金刚烷基)乙基胺盐酸盐)

一般描述

Rimantadine Hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.

别 称

Flumadine; Meradane; 1-(1-Aminoethyl)Adamantane Hydrochloride; 1-(1-adamantyl)ethanamine; hydrochloride   

纯 度

≥99.0%(with Total Nitrogen)

CAS NO.

1501-84-4

分子式

C¹²H²²ClN

分子量

215.76

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

≥35mg/ml

l  生物学信息

生物活性/药理作用

Rimantadine Hydrochloride is the  hydrochloride salt form of rimantadine, a cyclic amine and alpha-methyl derivative of amantadine with antiviral activity. Although the exact mechanism of action of rimantadine is not understood, this agent appears to exert its antiviral effect against influenza A virus by interfering with the function of the transmembrane  domain of the viral M2 protein, thereby preventing the uncoating of the virus and subsequent release of infectious viral nucleic acids into the cytoplasm of infected cells.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov