产品名称

Amantadine(1-金刚烷胺)

一般描述

Amantadine is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.

别 称

1-Adamantylamine, 1-Aminoadamantane; adamantan-1-amine 

纯 度

≥98.0%(GC)

CAS NO.

768-94-5

分子式

C¹⁰H¹⁷N

分子量

151.25

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至类白色固体

溶解性(25°C)

DMSO

Slightly soluble

l  生物学信息

生物活性/药理作用

Amantadine is a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells. Furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine  from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov