产品名称

Amodiaquine hydrochloride(盐酸阿莫地喹)

一般描述

Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine with antimalarial and anti-inflammatory properties.

别 称

Amodiaquin Dihydrochloride; 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol; dihydrochloride 

纯 度

≥98.0%(HPLC)

CAS NO.

69-44-3

分子式

C²⁰H²⁴Cl³N³O

分子量

428.78

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥45mg/ml

l  生物学信息

生物活性/药理作用

Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov