产品名称

Doripenem(多尼培南)

一般描述

Doripenem is a new member of the carbapenem class of beta-lactam antibiotics with  broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens.

别 称

Doribax; Doripenem Hydrate; Finibax

纯 度

≥98.0%(HPLC)

CAS NO.

148016-81-3

分子式

C¹⁵H²⁴N⁴O⁶S²

分子量

420.50426

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥50mg/ml

l  生物学信息

生物活性/药理作用

Doripenem is a broad-spectrum, carbapenem antibiotic with bactericidal and beta-lactamase resistant activities. Doripenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, particularly PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and eventually lysis of the bacterial cell wall. This agent is two- to 16-fold more potent than imipenem and comparable to ertapenem and meropenem.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov