产品名称

Clodronate disodium tetrahydrate(氯屈膦酸二钠四水合物)

一般描述

Clodronate is a non-nitrogenous bisphosphonate that can bind to bone to reduce the bone resorption. It is used as an anti-osteoporotic drug for the prevention of osteoporosis in post-menopausal women and men.

别 称

Disodium Clodronate Tetrahydrate; Clodronate Disodium Tetrahydrate

纯 度

≥98.0%(T)

CAS NO.

88416-50-6

分子式

CH¹⁰Cl²Na²O¹⁰P²

分子量

360.917162

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

Very slightly soluble

水

≥50mg/ml

l  生物学信息

生物活性/药理作用

Clodronate Disodium is the disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov