产品名称

Splitomicin

一般描述

Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay. 

别 称

1,2-dihydrobenzo[f]chromen-3-one

纯 度

≥98.5%(HPLC)

CAS NO.

5690-03-9

分子式

C¹³H¹⁰O²

分子量

198.22

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25°C)

DMSO

≥25mg/ml

乙醇

≥25mg/ml

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Splitomicin is a benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins. It has a role as a Sir2 inhibitor and a platelet aggregation inhibitor. It is a benzochromenone and a delta-lactone.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov