产品名称

Napabucasin

一般描述

Napabucasin is an orally available Stat3 and cancer cell stemness inhibitor. 

别 称

BBI608; 2-acetylbenzo[f][1]benzofuran-4,9-dione

纯 度

≥98.5%(HPLC)

CAS NO.

83280-65-3

分子式

C¹⁴H⁸O⁴

分子量

240.21

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

棕色固体

溶解性(25°C)

DMSO

≥5mg/ml

乙醇

Insoluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Napabucasin is an orally available cancer cell stemness inhibitor with potential antineoplastic activity. Even though the exact target has yet to be fully elucidated, napabucasin appears to target and inhibit multiple pathways involved in cancer cell stemness. This may ultimately inhibit cancer stemness cell (CSC) growth as well as heterogeneous cancer cell growth. CSCs, self-replicating cells that are able to differentiate into heterogeneous cancer cells, appear to be responsible for the malignant growth, recurrence and resistance to conventional chemotherapies.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov