Homoharringtonine
商品编号:
TS3661
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详细介绍
l 基本信息 |
产品名称 | Homoharringtonine(高三尖杉酯碱) |
一般描述 | Homoharringtonine is a cytotoxic alkaloid, induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 26833-87-4 |
分子式 | C29H39NO9 | 分子量 | 545.62126 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至米色固体 |
溶解性(25°C) | DMSO | ≥50mg/ml |
l 生物学信息 |
生物活性/药理作用 | Omacetaxine Mepesuccinate is a semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine mepesuccinate binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types. |
l 存储 |
存储温度 | -20°C |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |