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  • DNA Ligase from T4-infected Escherichia coli
    TS3545

    CCG-203971 is a novel small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene tranion.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3550

    GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1) ≥400-fold selective for GRK2 over both GRK1 and GRK5.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3555

    KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM.  

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  • DNA Ligase from T4-infected Escherichia coli
    TS3562

    Senexin A is a potent and selective inhibitor of CDK8 and its nearest relative, CDK19 with Kd values of 0.83 μM and 0.31 μM for CDK8 and CDK19 ATP site binding, respectively.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3610

    Chk2 Inhibitor II (BML-277) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3623

    PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3640

    SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2.

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