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  • DNA Ligase from T4-infected Escherichia coli
    TS3583

    Chidamide is a low nanomolar inhibitor of HDAC1, 2, 3, and 10, the HDAC isotypes well documented to be associated with the malignant phenotype with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3598
    CP2

    CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.  

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  • DNA Ligase from T4-infected Escherichia coli
    TS3601

    JQ-EZ-05 is a specific and reversible EZH1/2 inhibitor.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3608

    OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3618

    ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3625

    GSK3326595 (EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.

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