BAF312(辛波莫德) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors.

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.    

HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.  

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.  

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM.

Ozanimod(奥扎莫德) is a selective oral S1P Receptor 1 modulator.

L-755507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.