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  • DNA Ligase from T4-infected Escherichia coli
    TS1347
    Ammonium pyrrolidine dithiocarbamate (PDTC)(吡咯烷二硫代甲酸铵盐) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.
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  • DNA Ligase from T4-infected Escherichia coli
    TS1562
    Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.
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  • DNA Ligase from T4-infected Escherichia coli
    TS1740
    Sodium 4-Aminosalicylate(4-氨基水杨酸钠二水合物) is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.
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  • DNA Ligase from T4-infected Escherichia coli
    TS2256
    SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
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  • DNA Ligase from T4-infected Escherichia coli
    TS3020
    BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
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  • DNA Ligase from T4-infected Escherichia coli
    TS3056
    WS3
    WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
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  • DNA Ligase from T4-infected Escherichia coli
    TS3057
    WS6
    WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
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  • DNA Ligase from T4-infected Escherichia coli
    TS3181
    Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
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