24(S)-Hydroxycholesterol is the major brain metabolite formed from cholesterol in the brain and is important for brain cholesterol homeostasis in addition to being an an endogenous agonist of the nuclear liver X receptors (LXRs).

Hymeglusin is a specific β lactone inhibitor of eukaryotic hydroxymethylglutaryl-CoA synthase (HMGCS), a key enzyme in the cholesterol biosynthetic pathway.

LUF6283 is a partial agonist of the hydroxy-carboxylic acid receptor 2 (HCA2; GPR109A).

ML261 blocks lipid droplet formation in murine AML-12 hepatocytes grown in the presence of oleic acid, with an IC50 of 69.7 nM.

NDB is a selective antagonist of human Farnesoid X receptor α (FXRα) that effectively modulates FXRα down-stream genes.

M2 is a metabolite of the chemopreventive agent oltipraz.

PF-04445597 is a potent, orally bioavailable inhibitor of cholesteryl ester transfer protein (CETP).