GSK2292767 is a potent and selective PI3Kδ inhibitor.

ETC-1002,also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).

AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).

Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases.

ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.

Deguelin, a natural product isolated from plants in the Mundulea sericea family, is an  PI3K/AKT Inhibitor.

GDC-0326 is a potent and selective inhibitor of PI3Kα with Ki value of 0.2 nM remarkably selective over the other class I isoforms in enzymatic assays.