MX69, a MDM2/XIAP inhibitor, binds to MDM2 RING protein with binding Kd values of 2.34 μM.
Bioymifi is a small-molecule death receptor 5 (DR5) agonist.
Necrostatin-1 is a specific RIP1 inhibitor.
NSC348884 is a nucleophosmin inhibitor.
Pifithrin-β hydrobromide is an inhibitor of p53, reversibly blocks p53-dependent tranional activation and apoptosis.
Salubrinal is a selective inhibitor of eIF2α dephosphorylation.
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor.
CBL0137 activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively.