Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.
Pomalidomide is an orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities.
EVP4593 shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.
Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist.
Sepantronium Bromide is a small-molecule proapoptotic agent with potential antineoplastic activity.
AT406 is a potent Smac mimetic and an antagonist of IAP.
BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.
GSK2606414 is an orally available, potent, and selective PERK inhibitor.