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  • DNA Ligase from T4-infected Escherichia coli
    TS3204

    APR-246, also known as PRIMA-1MET, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3226

    Emricasan(恩利卡生) is a potent irreversible pan-caspase inhibitor.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3228

    A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.  

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  • DNA Ligase from T4-infected Escherichia coli
    TS3234

    A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).

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  • DNA Ligase from T4-infected Escherichia coli
    TS3258

    BDA-366 is a small-molecule Bcl2-BH4 domain antagonist and binds BH4 with high affinity and selectivity. It directly binds to Bcl2 with high binding affinity (Ki =3.3 ± 0.73 nM).

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  • DNA Ligase from T4-infected Escherichia coli
    TS3267

    NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3278

    Ac-DEVD-CHO is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3361

    Sabutoclax is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

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