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  • DNA Ligase from T4-infected Escherichia coli
    TS0303

    XMD8-92 is a potent and selective BMK1/ERK5 inhibitor.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0304

    Ulixertinib is an orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0305

    GDC-0994 is a potent, orally available and highly selective ERK1/2 inhibitor.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0497

    SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKIIcapable of transport through the blood-brain barrier.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0499

    Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0618

    VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0645

    BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0655

    PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

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