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  • DNA Ligase from T4-infected Escherichia coli
    TS3536

    8-OH-DPAT(8-Hydroxy-DPAT) is a kind of classic 5-HT1A agonist with the pIC50 of 8.19. It has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site Its biological half-life is 1.5 hours.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3561

    A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3581

    Verubecestat (MK-8931) is a potent and selective beta-secretase (also known as Beta-site APP-cleaving enzyme 1) inhibitor.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3599

    NGP 555 is a small-molecule modulator of  γ-secretase and has been successful in achieving good oral absorption, brain penetration, CNS activity, and specificity for a lipid-based membrane target preclinically.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3816

    Xanthotoxol(花椒毒酚) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects.

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  • DNA Ligase from T4-infected Escherichia coli
    TS3878

    Isocorynoxeine(异去氢钩藤碱), an isorhynchophylline-related alkaloid, exhibits a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM.

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  • DNA Ligase from T4-infected Escherichia coli
    TS4073

    Metoclopramide(甲氧氯普胺) is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.  

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