NXY-059 (Disufenton sodium) is a novel nitrone, shows efficacious neuroprotective effects.
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively.
AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM, respectively.
GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively.
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21nM, while exhibiting 37,000-fold selectivity over human lysosomal –hexosaminidase.
OAC1(Oct4-activating compound 1) can enhance the efficiency of reprogramming.
SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..
4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.