Epothilone A(埃博霉素A) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.
Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A.
Albendazole(阿苯达唑亚砜) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.
Lexibulin is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines.
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1.
SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM.