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  • DNA Ligase from T4-infected Escherichia coli
    TS0559

    Epothilone A(埃博霉素A) is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0614

    Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0743

    Albendazole(阿苯达唑亚砜) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0890

    SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0893

    Lexibulin is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0908

    Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1.

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  • DNA Ligase from T4-infected Escherichia coli
    TS1095

    SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.

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  • DNA Ligase from T4-infected Escherichia coli
    TS1096

    PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM.

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