Calcitriol(骨化三醇) is a nive vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.

Doxercalciferol(度骨化醇) is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease.

Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is <300 nM in some cell lines.

Dyphylline(二羟丙茶碱) is a xanthine derivative with bronchodilator and vasodilator effects.

Pimobendan(匹莫苯丹) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.

Tazarotene is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.

Sulfameter(磺胺对甲氧嘧啶) is a long-acting sulfonamide antibacterial.

Aminophylline(氨茶碱) is a competitive nive phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nive adenosine receptor antagonist.