Amonafide(氨萘非特) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.

Mizoribine(咪唑立宾) is an imidazole nucleoside, selectively inhibits inosine monophosphate synthetase and guanosine monophosphate synthetase.

Pirarubicin(吡柔比星) is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into DNA and interacts with topoisomerase II, used as an antineoplastic agent.

Marbofloxacin(马波沙星) is a potent antibiotic inhibiting bacterial DNA replication.

Busulfan(白消安) is a cell cycle non-specific alkylating antineoplastic agent.

Vidarabine(阿糖腺苷) is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.

Rifaximin(利福昔明) is a RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.

Nedaplatin(奈达铂) is a derivative of cisplatin and DNA damage agent for tumor colony forming units with IC50 of 94 μM.